GBR 12935 dihydrochloride

Name: GBR 12935 dihydrochloride
Brand: Tocris Bioscience
SKU: 0514

Tocris Bioscience, part of Bio-Techne | Catalog # 0514

COA / SDS

Selective dopamine uptake inhibitor

Discontinued Product

0514 has been discontinued. View all Dopamine Transporter Inhibitors products.

Key Product Details

Description:	Selective dopamine uptake inhibitor
Chemical Name:	1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Molecular Weight:	487.51

View Full Technical Details for GBR 12935 dihydrochloride

Technical Data
Citations

Biological Activity for GBR 12935 dihydrochloride

GBR 12935 dihydrochloride is a potent and selective inhibitor of dopamine uptake (K_D = 5.5 nM in rat striatal membranes).

Technical Data for GBR 12935 dihydrochloride

M. Wt	487.51
Formula	C₂₈H₃₄N₂O.2HCl
Storage	Desiccate at -20°C
CAS Number	67469-81-2
PubChem ID	11957553
InChi Key	NQWRSILGEXNJIT-UHFFFAOYSA-N
Smiles	Cl.Cl.C(CN1CCN(CCOC(C2=CC=CC=C2)C2=CC=CC=C2)CC1)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GBR 12935 dihydrochloride

References are publications that support the biological activity of the product.

Reith GBR 12909 and 12935 block DA uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 1994 PMID: 8013544
Reith Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and DA to the DA transporter. Eur.J.Pharmacol. 1992 PMID: 1446712
Andersen Biochemical and pharmacological characterization of [³H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the DA uptake complex. J.Neurochem. 1987 PMID: 2952763

GBR 12935 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0514

Key Product Details

Biological Activity for GBR 12935 dihydrochloride

Technical Data for GBR 12935 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GBR 12935 dihydrochloride

Product Documents for GBR 12935 dihydrochloride

COA

Certificate of Analysis

SDS

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