GBR 12783 dihydrochloride

Name: GBR 12783 dihydrochloride
Brand: Tocris Bioscience
SKU: 0513
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0513

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Citations (9)

COA / SDS

Potent and selective DA uptake inhibitor

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective DA uptake inhibitor

View all Dopamine Transporter Inhibitors »

Product Description

GBR 12783 dihydrochloride is a very potent and selective inhibitor of dopamine uptake (IC₅₀ for inhibition of [³H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).

Product Specifications

Molecular Weight

485.50

Formula

C₂₈H₃₂N₂O.2HCl

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride

CAS Number

67469-75-4

PubChem ID

24744862

InChI Key

HJDXBLLTRMCYNC-JFXLULTRSA-N

SMILES

Cl[H].Cl[H].C(CN1CCN(C\C=C\C2=CC=CC=C2)CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.27	50

Preparing Stock Solutions for GBR 12783 dihydrochloride

The following data is based on the product molecular weight 485.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.12 mL	20.60 mL	41.19 mL
2.5 mM	0.82 mL	4.12 mL	8.24 mL
5 mM	0.41 mL	2.06 mL	4.12 mL
25 mM	0.08 mL	0.41 mL	0.82 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Vaugeois In vivo labelling of the neuronal DA uptake complex in the mouse striatum by [³H]GBR 12783. Eur.J.Pharmacol. 1992 PMID: 1350989
Do-Rego Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of DA. J.Neurochem. 1999 PMID: 9886093
Giros Cloning, pharmacological characterization and chromosome assignment of the human DA transporter. Mol.Pharmacol. 1992 PMID: 1406597
Bonnet and Constentin GBR 12783, a potent and selective inhibitor of DA uptake: biochemical studies in vivo and ex vivo. Eur.J.Pharmacol. 1986 PMID: 3754516