Gastrin I (human)

Name: Gastrin I (human)
Brand: Tocris Bioscience
SKU: 3006
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3006

Citations (75)

COA / SDS

Selective CCK2 agonist

Key Product Details

Description:	Selective CCK₂ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	2098.22

View Full Technical Details for Gastrin I (human)

Technical Data
Citations

Biological Activity for Gastrin I (human)

Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin I stimulates gastric epithelial cell proliferation and histamine secretion (EC₅₀ values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids. For more information about using Gastrin I in the generation of gastric organoids see the Human Gastric Organoid Culture Protocol.

Technical Data for Gastrin I (human)

M. Wt	2098.22
Formula	C₉₇H₁₂₄N₂₀O₃₁S
Single Letter Sequence	XGPWLEEEEEAYGWMDF (Modifications: X = Glp, Phe-17 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	10047-33-3
PubChem ID	16162108
InChi Key	GKDWRERMBNGKCZ-RNXBIMIWSA-N
Smiles	[H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gastrin I (human)

Solubility

Soluble to 1mg/ml in 1% Ammonia with sonication

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References for Gastrin I (human)

References are publications that support the biological activity of the product.

Kidd A comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation. Regul.Pept. 2007 PMID: 17531331
Bartfeld In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 2015 PMID: 25307862
Mahe Establishment of gastrointestinal epithelial organoids Curr.Protoc. Mouse Biol. 2014 PMID: 25105065
Sato SnapShot: Growing Organoids from Stem Cells. Cell 2015 PMID: 26091044
Blandizzi CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur.J.Pharmacol. 1999 PMID: 10408253
Noble International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol.Rev. 1999 PMID: 10581329