Gallein
Tocris Bioscience, part of Bio-Techne | Catalog # 3090
Inhibitor of Gβ/γ signaling
Key Product Details
Description
Inhibitor of Gβ/γ signaling
Product Description
Gallein is an inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.Product Specifications
Molecular Weight
364.31
Formula
C20H12O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
3',4',5',6'-Tetrahydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one
CAS Number
2103-64-2
PubChem ID
73685
InChI Key
PHLYOKFVXIVOJC-UHFFFAOYSA-N
SMILES
OC1=CC=C(C(C(C=CC=C5)=C5C(O4)=O)4C(C=CC(O)=C3O)=C3O2)C2=C1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.32 | 75 | |
| Ethanol | 3.64 | 10 |
Preparing Stock Solutions
for Gallein
The following data is based on the product molecular weight 364.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 3.66 mL | 18.30 mL | 36.60 mL |
| 3.75 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 7.5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 37.5 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ukhanov Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J.Neurosci. 2011 PMID: 21209212
- Lehmann Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol.Pharmacol. 2008 PMID: 18006643
Product Specific Notices for Gallein
For research use only
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