Gadolinium chloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4741
Stretch-activated calcium channel blocker; calcium-sensing receptor agonist
Discontinued Product
4741 has been discontinued.
View all Other Calcium Channel Compounds products.
Key Product Details
Description
Stretch-activated calcium channel blocker; calcium-sensing receptor agonist
Product Description
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.Product Specifications
Molecular Weight
263.61
Formula
GdCl3
Storage
Desiccate at RT
CAS Number
10138-52-0
PubChem ID
61486
InChI Key
MEANOSLIBWSCIT-UHFFFAOYSA-K
SMILES
Cl[Gd](Cl)Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.36 | 100 |
Preparing Stock Solutions
for Gadolinium chloride
The following data is based on the product molecular weight 263.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.79 mL | 18.97 mL | 37.93 mL |
| 5 mM | 0.76 mL | 3.79 mL | 7.59 mL |
| 10 mM | 0.38 mL | 1.90 mL | 3.79 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nagata The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 18162548
- Lee The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 2012 PMID: 23143333
- Del Favero The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 2012 PMID: 22900474
- Nishitani Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 2011 PMID: 22053183
Product Specific Notices for Gadolinium chloride
For research use only
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