G6PDi 1

Name: G6PDi 1
Brand: Tocris Bioscience
SKU: 7561

Tocris Bioscience, part of Bio-Techne | Catalog # 7561

Citations (1)

COA / SDS

Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor

Key Product Details

Description:	Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor
Chemical Name:	4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	284.34

View Full Technical Details for G6PDi 1

Technical Data
Citations

Biological Activity for G6PDi 1

G6PDi 1 is a potent, reversible, nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD) (IC₅₀ = 70 nM. The compound dose-dependently and reversibly decreases 6-phosphogluconolactone (6-PG) levels in HCT116 and HepG2 cell lines in vitro. In activated T cells, G6PDi-1 inhibits flux through the pentose phosphate pathway and decreases NADPH generation. It also inhibits production of cytokines by activated T cells and oxidative burst in neutrophils.

Licensing Information

Sold under license from Princeton University

Technical Data for G6PDi 1

M. Wt	284.34
Formula	C₁₄H₁₂N₄OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2457232-14-1
PubChem ID	145998284
InChi Key	USWCHVCZOGGQQA-UHFFFAOYSA-N
Smiles	O=C1CCCCC2=NC(NC3=CSC(C#N)=C3)=NC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G6PDi 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.43	100

Preparing Stock Solutions for G6PDi 1

The following data is based on the product molecular weight 284.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.58 mL	35.17 mL
5 mM	0.70 mL	3.52 mL	7.03 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for G6PDi 1

References are publications that support the biological activity of the product.

Ghergurovich A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat.Chem.Biol. 2020 PMID: 32393898