G10

Name: G10
Brand: Tocris Bioscience
SKU: 5944

Tocris Bioscience, part of Bio-Techne | Catalog # 5944

COA / SDS

Activator of STING-dependent signaling

Discontinued Product

5944 has been discontinued. View all STING/TMEM173 products.

Key Product Details

Description:	Activator of STING-dependent signaling
Chemical Name:	4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	430.88

View Full Technical Details for G10

Technical Data
Citations

Biological Activity for G10

G10 is an activator of STING-dependent signaling; exhibits no direct binding affinity for STING. Stimulates IRF-3-induced transcription and induces IFNα and IFNγ gene expression in human fibroblasts. Exhibits no effect on NF-κB signaling. Blocks viral replication in vitro.

Compound Libraries for G10

G10 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for G10

M. Wt	430.88
Formula	C₂₁H₁₆ClFN₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	702662-50-8
PubChem ID	5077622
InChi Key	NAGKYJATVFXZKN-UHFFFAOYSA-N
Smiles	FC1=CC=CC(Cl)=C1CN2C(CSC3=CC=C(C(NCC4=CC=CO4)=O)C=C23)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for G10

References are publications that support the biological activity of the product.

Sali Characterization of a novel human-specific STING agonist that elicits antiviral activity against emerging alphaviruses. PLoS Pathog. 2015 PMID: 26646986

G10

Tocris Bioscience, part of Bio-Techne | Catalog # 5944

Key Product Details

Biological Activity for G10

Compound Libraries for G10

Technical Data for G10

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for G10

Product Documents for G10

COA

Certificate of Analysis

SDS

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