G-36

Tocris Bioscience, part of Bio-Techne | Catalog # 4759

Selective GPER antagonist
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Key Product Details

Description

Selective GPER antagonist

View all Estrogen and Related Receptor Antagonists »

Product Description

G-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC50 = 112 nM). Structural analog of G-1 (Cat. No. 3577).

Product Specifications

Molecular Weight

412.33

Formula

C22H22BrNO2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

CAS Number

1392487-51-2

PubChem ID

73755224

InChI Key

QTOCPACSSHFGOY-ZCCHDVMBSA-N

SMILES

BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC(C(C)C)=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.23 100

Preparing Stock Solutions for G-36

The following data is based on the product molecular weight 412.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.13 mL 24.25 mL
5 mM 0.49 mL 2.43 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for G-36

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for G-36

For research use only

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