FzM1.8

Name: FzM1.8
Brand: Tocris Bioscience
SKU: 6961

Tocris Bioscience, part of Bio-Techne | Catalog # 6961

Citations (2)

COA / SDS

Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness

Key Product Details

Description:	Frizzled 4 allosteric agonist; exhibits biased signaling; preserves stemness
Chemical Name:	3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	322.32

View Full Technical Details for FzM1.8

Technical Data
Citations

Biological Activity for FzM1.8

FzM1.8 is a frizzled 4 allosteric agonist (pEC₅₀ = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.

Compound Libraries for FzM1.8

FzM1.8 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for FzM1.8

M. Wt	322.32
Formula	C₁₈H₁₄N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2204290-85-5
PubChem ID	137553171
InChi Key	XGNNCRZDDAJBFU-UHFFFAOYSA-N
Smiles	OC(=O)C1=CC(O)=CC(NC(=O)NC2=CC3=C(C=CC=C3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FzM1.8

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.23	100

Preparing Stock Solutions for FzM1.8

The following data is based on the product molecular weight 322.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.51 mL	31.03 mL
5 mM	0.62 mL	3.10 mL	6.21 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for FzM1.8

References are publications that support the biological activity of the product.

Riccio A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist. Biochemistry 2018 PMID: 29293331