FTI 277

Tocris Bioscience, part of Bio-Techne | Catalog # 2407

Prodrug form of FTI 276 (Cat. No. 2406)
Discontinued Product
2407 has been discontinued. View all Other Transferase Inhibitors products.

Key Product Details

Description

Prodrug form of FTI 276 (Cat. No. 2406)

View all Other Transferase Inhibitors »

Product Description

FTI 277 is a prodrug form of FTI 276 (Cat. No. 2406) that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

Product Specifications

Molecular Weight

561.64

Formula

C22H29N3O3S2.C2HF3O2

Storage

Store at -80°C

Purity

≥95% (HPLC)

Chemical Name

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt

CAS Number

1217447-06-7

PubChem ID

71311821

InChI Key

GJEFFRDWFVSCOJ-PXPMWPIZSA-N

SMILES

SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](OC)=O)CCSC)=O)C(C2=CC=CC=C2)=C1.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.81 5

Preparing Stock Solutions for FTI 277

The following data is based on the product molecular weight 561.64

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 35.61 mL 178.05 mL 356.10 mL
0.25 mM 7.12 mL 35.61 mL 71.22 mL
0.5 mM 3.56 mL 17.80 mL 35.61 mL
2.5 mM 0.71 mL 3.56 mL 7.12 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for FTI 277

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FTI 277

For research use only

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