FTBMT
Tocris Bioscience, part of Bio-Techne | Catalog # 6784
Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
Key Product Details
Description
Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
Alternative Names
TP-024
Product Description
FTBMT (also known as TP 024) is a potent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%), which is selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. FTBMT suppresses methamphetamine-induced hyperlocomotion in mice, and inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. This compound is orally bioavailable and brain penetrant.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of FTBMT (TP 024) is reviewed on chemicalprobes.org and the SGC website.Product Specifications
Molecular Weight
392.35
Formula
C19H16F4N4O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide
CAS Number
1358575-02-6
PubChem ID
56649300
InChI Key
TYXSIXOYTBHZFA-UHFFFAOYSA-N
SMILES
CC1=NC(CC2=CC(C(F)(F)F)=CC(F)=C2)=NN1C3=CC(C)=C(C(N)=O)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.23 | 100 | |
| Ethanol | 19.62 | 50 |
Preparing Stock Solutions
for FTBMT
The following data is based on the product molecular weight 392.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.49 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nishiyama FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 2017 PMID: 28851764
- Tokumaru Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 2017 PMID: 28433511
Product Specific Notices for FTBMT
For research use only
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