FSLLRY-NH2
Tocris Bioscience, part of Bio-Techne | Catalog # 4751
PAR2 peptide antagonist
Key Product Details
Description
PAR2 peptide antagonist
Product Description
FSLLRY-NH2 is a selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.Product Specifications
Molecular Weight
796.97
Formula
C39H60N10O8
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
245329-02-6
PubChem ID
73352412
InChI Key
KMSCNWHRNILNRJ-JNRWAQIZSA-N
SMILES
[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
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Background References
References are publications that support the biological activity of the product.
- Kumar Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front.Immunol. 2022 PMID: 35844627
- Chen Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain. Neuroscience 2011 PMID: 21763756
- Andoh Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 2012 PMID: 22761302
- McLarty Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 2011 PMID: 21730297
Product Specific Notices for FSLLRY-NH2
For research use only
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