FSL 1

Name: FSL 1
Brand: Tocris Bioscience
SKU: 6011
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6011

(1)

COA / SDS

TLR2/6 agonist (also a putative TLR10 ligand)

Discontinued Product

6011 has been discontinued. View all Toll-like Receptor Agonists products.

Key Product Details

Description:	TLR2/6 agonist (also a putative TLR10 ligand)
Purity:	≥95% (HPLC)
Molecular Weight:	1666.16

View Full Technical Details for FSL 1

Technical Data
Citations / Reviews (1)

Biological Activity for FSL 1

FSL 1 is a TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Technical Data for FSL 1

M. Wt	1666.16
Formula	C₈₄H₁₄0N₁₄O₁₈S
Single Letter Sequence	CGDPKHPKSF (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	322455-70-9
PubChem ID	87858248
InChi Key	VJJLLNHELGKSNA-YWKNMTRCSA-N
Smiles	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for FSL 1

References are publications that support the biological activity of the product.

Mauldin TLR2/6 agonists and IF.-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 2015 PMID: 25765738
Le Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 2016 PMID: 27258267
Okusawa Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 2004 PMID: 14977973

FSL 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6011

Key Product Details

Biological Activity for FSL 1

Technical Data for FSL 1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for FSL 1

Product Documents for FSL 1

COA

Certificate of Analysis

SDS

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