Fostriecin sodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 1840

Potent PP2A and PP4 inhibitor
Discontinued Product
1840 has been discontinued. View all Protein Ser/Thr Phosphatase Inhibitors products.

Key Product Details

Description

Potent PP2A and PP4 inhibitor

View all Protein Ser/Thr Phosphatase Inhibitors »

Product Description

Fostriecin sodium salt is a potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

Product Specifications

Molecular Weight

452.37

Formula

C19H26O9PNa

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

CAS Number

87860-39-7

PubChem ID

16759606

InChI Key

XBUIKNRVGYFSHL-IAVQPKKASA-M

SMILES

[Na+].C[C@@](O)(\C=C\[C@H]1CC=CC(=O)O1)[C@@H](C[C@@H](O)\C=C/C=C\C=C\CO)OP(O)([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.24 100

Preparing Stock Solutions for Fostriecin sodium salt

The following data is based on the product molecular weight 452.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.11 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Product Documents for Fostriecin sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fostriecin sodium salt

For research use only

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