FMK 9a
Tocris Bioscience, part of Bio-Techne | Catalog # 7496
Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B
Key Product Details
Description
Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B
Product Description
FMK 9a is a potent ATG4B/autophagin-1 inhibitor (IC50 values are 73 nM and 80 nM in cell-based LRA and TR-FRET assays, respectively). Also inhibits calpain and cathepsin B (IC50 values are 96 nM and 200 nM, respectively).Product Specifications
Molecular Weight
392.43
Formula
C23H21FN2O3
Storage
Store at -20°C
Purity
≥90% (HPLC)
Chemical Name
N-[(1S)-2-[(3-Fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-1-naphthalenecarboxamide
CAS Number
1955550-51-2
PubChem ID
127020966
InChI Key
VMVOHHPQIAPYHG-NRFANRHFSA-N
SMILES
FCC(CNC([C@@H](NC(C1=CC=CC2=C1C=CC=C2)=O)CC3=CC=CC=C3)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.24 | 100 |
Preparing Stock Solutions
for FMK 9a
The following data is based on the product molecular weight 392.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Qiu Discovery of fluoromethylketone-based peptidomimetics as covalent ATG4B (autophagin-1) inhibitors. ACS Med.Chem.Lett. 2016 PMID: 27563406
Product Specific Notices for FMK 9a
For research use only
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