Fluticasone propionate
Tocris Bioscience, part of Bio-Techne | Catalog # 2007
Selective high affinity glucocorticoid receptor agonist
Key Product Details
Description
Selective high affinity glucocorticoid receptor agonist
Product Description
Fluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
500.57
Formula
C25H31F3O5S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
CAS Number
80474-14-2
PubChem ID
444036
InChI Key
WMWTYOKRWGGJOA-CENSZEJFSA-N
SMILES
O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.03 | 50 |
Preparing Stock Solutions
for Fluticasone propionate
The following data is based on the product molecular weight 500.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.00 mL | 19.98 mL | 39.95 mL |
| 2.5 mM | 0.80 mL | 4.00 mL | 7.99 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 25 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pan Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 2012 PMID: 22803826
- Zhang Enhancement of human eosinophil apoptosis by flutic. propionate, budesonide, and beclometh. Eur.J.Pharmacol. 2000 PMID: 11040338
- Smith and Kreutner In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch.
- Johnson The anti-inflammatory profile of flutic. propionate. Allergy 1995 PMID: 7604948
Product Specific Notices for Fluticasone propionate
For research use only
⚠ WARNING: This product can expose you to chemicals including Fluticasone propionate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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