Flumazenil

Name: Flumazenil
Brand: Tocris Bioscience
SKU: 1328
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1328

(2)

Citations (50)

COA / SDS

Benzodiazepine antagonist

Key Product Details

Description:	Benzodiazepine antagonist
Alternative Names:	Ro 15-1788
Chemical Name:	8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	303.29

View Full Technical Details for Flumazenil

Technical Data
Citations / Reviews (2)

Biological Activity for Flumazenil

Flumazenil is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABA_A receptors. Centrally active upon systemic administration in vivo. Also inhibits repressor element-1 silencing transcription factor (REST) by targeting degradation.

Compound Libraries for Flumazenil

Flumazenil is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Flumazenil

M. Wt	303.29
Formula	C₁₅H₁₄FN₃O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	78755-81-4
PubChem ID	3373
InChi Key	OFBIFZUFASYYRE-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=C2CN(C)C(=O)C3=CC(F)=CC=C3N2C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Flumazenil

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		25

Preparing Stock Solutions for Flumazenil

The following data is based on the product molecular weight 303.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	13.19 mL	65.94 mL	131.89 mL
1.25 mM	2.64 mL	13.19 mL	26.38 mL
2.5 mM	1.32 mL	6.59 mL	13.19 mL
12.5 mM	0.26 mL	1.32 mL	2.64 mL

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Reconstitution Calculator

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References for Flumazenil

References are publications that support the biological activity of the product.

Dobl New insights into the mechanism of action of hypnotics. J.Psychopharmacol. 1999 PMID: 10667451
Polc Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788. Naunyn Schmiedebergs Arch.Pharmacol. 1981 PMID: 7196507
Atack Regional differences in the inhibition of mouse in vivo [³H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABA_A receptors. Neuropsychopharmacology 1999 PMID: 10063485