Flufenamic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 4522
Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
Key Product Details
Description
Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
Product Description
Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.Product Specifications
Molecular Weight
281.23
Formula
C14H10F3NO2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
CAS Number
530-78-9
PubChem ID
3371
InChI Key
LPEPZBJOKDYZAD-UHFFFAOYSA-N
SMILES
O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.12 | 100 | |
| Ethanol | 28.12 | 100 |
Preparing Stock Solutions
for Flufenamic acid
The following data is based on the product molecular weight 281.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.56 mL | 17.78 mL | 35.56 mL |
| 5 mM | 0.71 mL | 3.56 mL | 7.11 mL |
| 10 mM | 0.36 mL | 1.78 mL | 3.56 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- White and Aylwin Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol.Pharmacol. 1990 PMID: 1692608
- Foster Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium 2009 PMID: 19232718
- Chi Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J.Pharmacol.Exp.Ther. 2011 PMID: 21765041
- Tu Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J.Neurochem. 2009 PMID: 19094061
Product Specific Notices for Flufenamic acid
For research use only
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