Fludarabine

Name: Fludarabine
Brand: Tocris Bioscience
SKU: 3495
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3495

(1)

Citations (34)

COA / SDS

Purine analog; inhibits DNA synthesis

Key Product Details

Description:	Purine analog; inhibits DNA synthesis
Chemical Name:	9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Purity:	≥98% (HPLC)
Molecular Weight:	285.23

View Full Technical Details for Fludarabine

Technical Data
Citations / Reviews (1)

Biological Activity for Fludarabine

Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC₅₀ = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

Compound Libraries for Fludarabine

Fludarabine is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fludarabine

M. Wt	285.23
Formula	C₁₀H₁₂FN₅O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	21679-14-1
PubChem ID	657237
InChi Key	HBUBKKRHXORPQB-FJFJXFQQSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fludarabine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.52	100

Preparing Stock Solutions for Fludarabine

The following data is based on the product molecular weight 285.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.51 mL	17.53 mL	35.06 mL
5 mM	0.70 mL	3.51 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.51 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for Fludarabine

References are publications that support the biological activity of the product.

Frank Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat.Med. 1999 PMID: 10202937
Meng Antitumor activity of fludar. against human multiple myeloma in vitro and in vivo. Eur.J.Haematol. 2007 PMID: 17976186
Torella Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 2007 PMID: 17293493
Bellosillo In vitro evaluation of fludar. in combination with cyclophosph. and/or mitoxan. in B-cell chronic lymphocytic leukemia. Blood 1999 PMID: 10515887