Fisetin
Tocris Bioscience, part of Bio-Techne | Catalog # 5016
Naturally occuring flavonoid and antioxidant; neuroprotective
Key Product Details
Description
Naturally occuring flavonoid and antioxidant; neuroprotective
Product Description
Fisetin is a naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.Product Specifications
Molecular Weight
286.24
Formula
C15H10O6
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
CAS Number
528-48-3
PubChem ID
5281614
InChI Key
XHEFDIBZLJXQHF-UHFFFAOYSA-N
SMILES
OC2=C(C3=CC=C(O)C(O)=C3)OC1=CC(O)=CC=C1C2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.62 | 100 | |
| Ethanol | 2.86 | 10 |
Preparing Stock Solutions
for Fisetin
The following data is based on the product molecular weight 286.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.49 mL | 17.47 mL | 34.94 mL |
| 5 mM | 0.70 mL | 3.49 mL | 6.99 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.49 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lee Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 2005 PMID: 16037419
- Maher ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum.Mol.Genet. 2011 PMID: 20952447
- Adhami Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem.Pharmacol. 2012 PMID: 22842629
- Haddad Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr.Cancer 2010 PMID: 20574928
- Lu Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J.Med.Chem. 2005 PMID: 15689157
Product Specific Notices for Fisetin
For research use only
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