Finasteride
Tocris Bioscience, part of Bio-Techne | Catalog # 3293
Type II 5α-reductase inhibitor
Key Product Details
Description
Type II 5α-reductase inhibitor
Alternative Names
MK 906
Product Description
Finasteride is an antiandrogen that inhibits type II 5α reductase (IC50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.Product Specifications
Molecular Weight
372.54
Formula
C23H36N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
CAS Number
98319-26-7
PubChem ID
57363
InChI Key
DBEPLOCGEIEOCV-WSBQPABSSA-N
SMILES
C[C@@]12[C@](CC[C@@H]2C(NC(C)(C)C)=O)([H])[C@]3([H])CC[C@@]4([H])NC(C=C[C@]4(C)[C@@]3([H])CC1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.25 | 100 | |
| Ethanol | 37.25 | 100 |
Preparing Stock Solutions
for Finasteride
The following data is based on the product molecular weight 372.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.42 mL | 26.84 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gao Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 2004 PMID: 15308613
- Mukai Studies on neurosteroids XXV. Influence of a 5α-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol.Pharm.Bull. 2008 PMID: 18758053
- Thigpen and Russell Four-amino acid segment in steroid 5α-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. J.Biol.Chem. 1992 PMID: 1314830
Product Specific Notices for Finasteride
For research use only
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