FIN 56
Tocris Bioscience, part of Bio-Techne | Catalog # 6280
Ferroptosis activator
Product Description
FIN 56 is a bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q10 depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).Product Specifications
Molecular Weight
517.66
Formula
C25H31N3O5S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
CAS Number
1083162-61-1
PubChem ID
118986699
InChI Key
JLCFMMIWBSZOIS-UHFFFAOYSA-N
SMILES
ON=C1C2=CC(=CC=C2C2=CC=C(C=C12)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.77 | 100 |
Preparing Stock Solutions
for FIN 56
The following data is based on the product molecular weight 517.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.66 mL | 19.32 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cotto-Rios and Gavathiotis Chemical genetics: Unraveling cell death mysteries. Nat.Chem.Biol. 2016 PMID: 27315536
- Shimada Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat.Chem.Biol. 2016 PMID: 27159577
Product Specific Notices for FIN 56
For research use only
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