Febuxostat

Name: Febuxostat
Brand: Tocris Bioscience
SKU: 4427

Tocris Bioscience, part of Bio-Techne | Catalog # 4427

Citations (3)

COA / SDS

Xanthine oxidase inhibitor

Key Product Details

Description:	Xanthine oxidase inhibitor
Alternative Names:	TEI 6720,TMX 67
Chemical Name:	2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	316.37

View Full Technical Details for Febuxostat

Technical Data
Citations

Biological Activity for Febuxostat

Febuxostat is a non-purine inhibitor of xanthine oxidase (K_i = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.

Compound Libraries for Febuxostat

Febuxostat is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Febuxostat

M. Wt	316.37
Formula	C₁₆H₁₆N₂O₃S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	144060-53-7
PubChem ID	134018
InChi Key	BQSJTQLCZDPROO-UHFFFAOYSA-N
Smiles	CC1=C(C(O)=O)SC(C2=CC(C#N)=C(OCC(C)C)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Febuxostat

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.73	75
	ethanol	15.82	50

Preparing Stock Solutions for Febuxostat

The following data is based on the product molecular weight 316.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.21 mL	21.07 mL	42.14 mL
3.75 mM	0.84 mL	4.21 mL	8.43 mL
7.5 mM	0.42 mL	2.11 mL	4.21 mL
37.5 mM	0.08 mL	0.42 mL	0.84 mL

Molarity Calculator

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Reconstitution Calculator

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References for Febuxostat

References are publications that support the biological activity of the product.

Xu Xanthine oxidase inhibition with febux. attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 2008 PMID: 18995179
Okamoto An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 2003 PMID: 12421831
Osada Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 1993 PMID: 8243554