Febuxostat
Tocris Bioscience, part of Bio-Techne | Catalog # 4427
Xanthine oxidase inhibitor
Key Product Details
Description
Xanthine oxidase inhibitor
Alternative Names
TEI 6720,TMX 67
Product Description
Febuxostat is a non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.Product Specifications
Molecular Weight
316.37
Formula
C16H16N2O3S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
CAS Number
144060-53-7
PubChem ID
134018
InChI Key
BQSJTQLCZDPROO-UHFFFAOYSA-N
SMILES
CC1=C(C(O)=O)SC(C2=CC(C#N)=C(OCC(C)C)C=C2)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.73 | 75 | |
| Ethanol | 15.82 | 50 |
Preparing Stock Solutions
for Febuxostat
The following data is based on the product molecular weight 316.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.21 mL | 21.07 mL | 42.14 mL |
| 3.75 mM | 0.84 mL | 4.21 mL | 8.43 mL |
| 7.5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
| 37.5 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xu Xanthine oxidase inhibition with febux. attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 2008 PMID: 18995179
- Okamoto An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 2003 PMID: 12421831
- Osada Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 1993 PMID: 8243554
Product Specific Notices for Febuxostat
For research use only
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