FAK Inhibitor 14

Name: FAK Inhibitor 14
Brand: Tocris Bioscience
SKU: 3414
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3414

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Citations (122)

COA / SDS

Selective FAK inhibitor

Key Product Details

Description:	Selective FAK inhibitor
Alternative Names:	Y15,NSC 677249
Chemical Name:	1,2,4,5-Benzenetetramine tetrahydrochloride
Molecular Weight:	284.01

View Full Technical Details for FAK Inhibitor 14

Technical Data
Citations / Reviews (1)

Biological Activity for FAK Inhibitor 14

FAK Inhibitor 14 is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. FAK Inhibitor 14 prevents FAK autophosphorylation at Y397 (IC₅₀ = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. FAK Inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo.

Compound Libraries for FAK Inhibitor 14

FAK Inhibitor 14 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for FAK Inhibitor 14

M. Wt	284.01
Formula	C₆H₁₀N₄.4HCl
Storage	Desiccate at RT
CAS Number	4506-66-5
PubChem ID	78260
InChi Key	BZDGCIJWPWHAOF-UHFFFAOYSA-N
Smiles	NC1=C(N)C=C(N)C(N)=C1.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FAK Inhibitor 14

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	14.2	50
	DMSO	21.3	75

Preparing Stock Solutions for FAK Inhibitor 14

The following data is based on the product molecular weight 284.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.69 mL	23.47 mL	46.95 mL
3.75 mM	0.94 mL	4.69 mL	9.39 mL
7.5 mM	0.47 mL	2.35 mL	4.69 mL
37.5 mM	0.09 mL	0.47 mL	0.94 mL

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References for FAK Inhibitor 14

References are publications that support the biological activity of the product.

Hochwald A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 2009 PMID: 19571674
Golubovskaya A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumour growth. J.Med.Chem. 2008 PMID: 18989950