Everolimus

Name: Everolimus
Brand: Tocris Bioscience
SKU: 6188

Tocris Bioscience, part of Bio-Techne | Catalog # 6188

Citations (16)

COA / SDS

mTOR inhibitor; Immunosuppressant

Key Product Details

Description:	mTOR inhibitor; Immunosuppressant
Alternative Names:	RAD001
Chemical Name:	42-O-(2-Hydroxyethyl)rapamycin
Purity:	≥98% (HPLC)
Molecular Weight:	958.22

View Full Technical Details for Everolimus

Technical Data
Citations

Biological Activity for Everolimus

Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.

Technical Data for Everolimus

M. Wt	958.22
Formula	C₅₃H₈₃NO₁₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	159351-69-6
PubChem ID	100926147
InChi Key	HKVAMNSJSFKALM-GKUWKFKPSA-N
Smiles	[H][C@@]12CC[C@H]([C@@](O1)(C(C(N3CCCC[C@]3(C(O[C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C2)\C)C)C)=O)OC)O)\C)C)=O)([C@@H](C[C@@H]4CC[C@H]([C@H](OC)C4)OCCO)C)[H])=O)[H])=O)=O)O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Everolimus

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	95.82	100
	ethanol	95.82	100

Preparing Stock Solutions for Everolimus

The following data is based on the product molecular weight 958.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.04 mL	5.22 mL	10.44 mL
5 mM	0.21 mL	1.04 mL	2.09 mL
10 mM	0.10 mL	0.52 mL	1.04 mL
50 mM	0.02 mL	0.10 mL	0.21 mL

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Reconstitution Calculator

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References for Everolimus

References are publications that support the biological activity of the product.

Sedrani Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc. 1998 PMID: 9723437
Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Lane mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin.Cancer Res. 2009 PMID: 19223496