Etomidate
Tocris Bioscience, part of Bio-Techne | Catalog # 1471
GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
Key Product Details
Description
GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
Product Description
Etomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.Product Specifications
Molecular Weight
244.29
Formula
C14H16N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
CAS Number
33125-97-2
PubChem ID
667484
InChI Key
NPUKDXXFDDZOKR-LLVKDONJSA-N
SMILES
O=C(OCC)C1=CN=CN1[C@@H]([C@@]2=CC=CC=C2)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 12.21 | 50 | |
| Ethanol | 24.43 | 100 |
Preparing Stock Solutions
for Etomidate
The following data is based on the product molecular weight 244.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.47 mL | 40.93 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Giese EtoM.: a new intravenous anesthetic induction agent. Pharmacother. 1983 PMID: 6359080
- Moody Distinct structural requirements for the direct and indirect actions of the anaesthetic EtoM. at GABAA receptors. Toxicol.Lett. 1998 PMID: 10049144
- Belelli The interaction of the general anesthetic EtoM. with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 1997 PMID: 9380754
Product Specific Notices for Etomidate
For research use only
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