ESI 05
Tocris Bioscience, part of Bio-Techne | Catalog # 6320
Epac2 inhibitor
Product Description
ESI 05 is an EPAC2 inhibitor. Inhibits cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC50 = 0.4 μM).Product Specifications
Molecular Weight
274.38
Formula
C16H18O2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
CAS Number
5184-64-5
PubChem ID
272513
InChI Key
CGPHOZWFSFNOEQ-UHFFFAOYSA-N
SMILES
CC1=CC=C(S(=O)(C2=C(C=C(C=C2C)C)C)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.44 | 100 | |
| Ethanol | 27.44 | 100 |
Preparing Stock Solutions
for ESI 05
The following data is based on the product molecular weight 274.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.64 mL | 18.22 mL | 36.45 mL |
| 5 mM | 0.73 mL | 3.64 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.64 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tsalkova Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.USA. 2012 PMID: 23091014
Product Specific Notices for ESI 05
For research use only
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