ERB 041
Tocris Bioscience, part of Bio-Techne | Catalog # 4276
Potent ERβ agonist
Key Product Details
Description
Potent ERβ agonist
Product Description
ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
271.24
Formula
C15H10FNO3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
CAS Number
524684-52-4
PubChem ID
5326893
InChI Key
FCXYSEXZEGPLGG-DHDCSXOGSA-N
SMILES
C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.12 | 100 | |
| Ethanol | 27.12 | 100 |
Preparing Stock Solutions
for ERB 041
The following data is based on the product molecular weight 271.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.43 mL | 36.87 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.37 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Malamas Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 2004 PMID: 15456246
- Cvoro Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 2008 PMID: 18097065
- Harris Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 2003 PMID: 14500559
Product Specific Notices for ERB 041
For research use only
Loading...
Loading...