EPPTB

Product Description

EPPTB is a trace amine 1 (TA₁) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA₁ receptor than the rat and human TA₁ receptors (IC₅₀ values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA₁ receptor-mediated activation of an inwardly rectifying K⁺ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D₂ receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC₅₀ = 19 nM).

Solubility

Preparing Stock Solutions for EPPTB

The following data is based on the product molecular weight 378.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.21 mL	26.43 mL
5 mM	0.53 mL	2.64 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bradaia The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in DArgic neurons of the mesolimbic system. Proc.Natl.Acad.Sci.U.S.A. 2009 PMID: 19892733