Endothelin 3 (human, rat)

Name: Endothelin 3 (human, rat)
Brand: Tocris Bioscience
SKU: 1162
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1162

Citations (5)

COA / SDS

Potent vasoconstrictor

Key Product Details

Description:	Potent vasoconstrictor
Alternative Names:	ET-3
Purity:	≥95% (HPLC)
Molecular Weight:	2643

View Full Technical Details for Endothelin 3 (human, rat)

Technical Data
Citations

Biological Activity for Endothelin 3 (human, rat)

Endothelin 3 (human, rat) is an endogenous neuropeptide and potent vasoconstrictor. Displays selectivity for the putative ET_C endothelin receptor.

Technical Data for Endothelin 3 (human, rat)

M. Wt	2643
Formula	C₁₂₁H₁₆₈N₂₆O₃₃S₄
Single Letter Sequence	CTCFTYKDKECVYYCHLDIIW (Modifications: Disulfide bridges: 1-15, 3-11)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	117399-93-6
PubChem ID	16133809
InChi Key	OQGZWNZGVYLIFX-JQWUVQPESA-N
Smiles	[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Endothelin 3 (human, rat)

Solubility

Soluble to 1mg/ml in water

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References for Endothelin 3 (human, rat)

References are publications that support the biological activity of the product.

Servitja Involvement of ET_A and ET_B receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 1998 PMID: 9756390
Yanagisawa and Masaski Molecular biology and biochemistry of the endothelins. TiPS 1989 PMID: 2690429
Inoue The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 1989 PMID: 2649896