EG 00229 trifluoroacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 6986
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
Key Product Details
Description
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1
Product Description
EG 00229 trifluoroacetate is a neuropilin 1 (NRP1) antagonist; inhibits VEGFA binding to the NRP1 b1 CendR binding pocket. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Inhibits binding of CendR motif in S1 protein of SARS-CoV-2 to NRP1, and reduces efficiency of SARS-CoV-2 infection in Caco-2 cells.Product Specifications
Molecular Weight
611.59
Formula
C17H19N7O5S3.CF3CO2H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine trifluoroacetate
CAS Number
1210945-69-9
PubChem ID
45142253
InChI Key
ZYQBITUOSRZDTG-MERQFXBCSA-N
SMILES
O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O.FC(F)(F)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 2eq. NaOH | 61.16 | 100 | |
| DMSO | 61.16 | 100 |
Preparing Stock Solutions
for EG 00229 trifluoroacetate
The following data is based on the product molecular weight 611.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.18 mL | 16.35 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.27 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Daly Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 2020 PMID: 33082294
- Jarvis Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 2010 PMID: 20151671
Product Specific Notices for EG 00229 trifluoroacetate
For research use only
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