Ebselen

Name: Ebselen
Brand: Tocris Bioscience
SKU: 5245
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5245

(1)

Citations (16)

COA / SDS

Glutathione peroxidase mimic; peroxynitrite scavenger

Key Product Details

Description:	Glutathione peroxidase mimic; peroxynitrite scavenger
Chemical Name:	2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	274.18

View Full Technical Details for Ebselen

Technical Data
Citations / Reviews (1)

Biological Activity for Ebselen

Ebselen is a glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits ferroptosis. Also inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H⁺/K⁺-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B₁. Antioxidant and anti-inflammatory. Selectively inhibits G_q protein signaling and enhances differentiation of brown adipocytes. Inhibits SARS-CoV-2 M^pro in vitro (IC₅₀ = 0.67 μM in FRET assay)

Technical Data for Ebselen

M. Wt	274.18
Formula	C₁₃H₉NOSe
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	60940-34-3
PubChem ID	3194
InChi Key	DYEFUKCXAQOFHX-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1[Se]N2C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ebselen

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.42	100

Preparing Stock Solutions for Ebselen

The following data is based on the product molecular weight 274.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.65 mL	18.24 mL	36.47 mL
5 mM	0.73 mL	3.65 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.65 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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References for Ebselen

References are publications that support the biological activity of the product.

Jin Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020 PMID: 32272481
Xie Ferroptosis: process and function. Cell Death Differ. 2016 PMID: 26794443
Kuschak Cell-permeable high-affinity tracers for G_q proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 2019 PMID: 31881095
Fujisawa and Kadoma Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 2005 PMID: 16309189
Yang Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 2000 PMID: 11133813
Schewe Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 1995 PMID: 7590103