Dynole 34-2

Name: Dynole 34-2
Brand: Tocris Bioscience
SKU: 4222
Rating: 0 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4222

(1)

Citations (16)

COA / SDS

Dynamin I inhibitor

Key Product Details

Description:	Dynamin I inhibitor
Chemical Name:	2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Purity:	≥98% (HPLC)
Molecular Weight:	408.58

View Full Technical Details for Dynole 34-2

Technical Data
Citations / Reviews (1)

Biological Activity for Dynole 34-2

Dynole 34-2 is a dynamin I inhibitor (IC₅₀ = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC₅₀ = 5.0 μM).

Compound Libraries for Dynole 34-2

Dynole 34-2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Dynole 34-2

M. Wt	408.58
Formula	C₂₅H₃₆N₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1128165-88-7
PubChem ID	44157463
InChi Key	MYIMRONQBLZJFI-DYTRJAOYSA-N
Smiles	CN(C)CCCN2C1=CC=CC=C1C(/C=C(C(NCCCCCCCC)=O)\C#N)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dynole 34-2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.86	100
	ethanol	20.43	50

Preparing Stock Solutions for Dynole 34-2

The following data is based on the product molecular weight 408.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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Reconstitution Calculator

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References for Dynole 34-2

References are publications that support the biological activity of the product.

Hill Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 2010 PMID: 20426422
Hill Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 2009 PMID: 19459681