DX3-213B

Name: DX3-213B
Brand: Tocris Bioscience
SKU: 8070

Tocris Bioscience, part of Bio-Techne | Catalog # 8070

COA / SDS

Potent NDUFS7 antagonist

Key Product Details

Description:	Potent NDUFS7 antagonist
Chemical Name:	(4,4-Difluoro-1-piperidinyl)[(3R)-1-[[4-[(1-methylethyl)sulfonyl]phenyl]sulfonyl]-3-piperidinyl]methanone
Purity:	≥97% (HPLC)
Molecular Weight:	478.57

View Full Technical Details for DX3-213B

Technical Data
Citations

Biological Activity for DX3-213B

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I (also known as NDUFS7) antagonist (IC₅₀ = 3.6 nM). DX3-213B impairs ATP generation (IC₅₀ = 11 nM) and inhibits the proliferation of MIA PaCa-2 cells (IC₅₀ = 9 nM) in galactose-containing media. In vivo, DX3-213B significantly delays tumor growth in a syngeneic mouse model of pancreatic cancer. DX3-213B is orally bioavailable.

Licensing Information

Sold under license from the University of Michigan

Technical Data for DX3-213B

M. Wt	478.57
Formula	C₂₀H₂₈F₂N₂O₅S₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2749555-66-4
PubChem ID	162365370
InChi Key	HLSJMSNPBRGRGL-MRXNPFEDSA-N
Smiles	O=S(N1C[C@H](C(N2CCC(CC2)(F)F)=O)CCC1)(C3=CC=C(S(C(C)C)(=O)=O)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DX3-213B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.93	50

Preparing Stock Solutions for DX3-213B

The following data is based on the product molecular weight 478.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.18 mL	20.90 mL	41.79 mL
2.5 mM	0.84 mL	4.18 mL	8.36 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
25 mM	0.08 mL	0.42 mL	0.84 mL

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References for DX3-213B

References are publications that support the biological activity of the product.

Xue Multiparameter optimization of oxidative phosphorylation inhibitors for the treatment of pancreatic cancer. J.Med.Chem. 2022 PMID: 35167303
Xu First-in-class NADH/Ubiquinone oxidoreductase core subunit S7 (NDUFS7) antagonist for the treatment of pancreatic cancer. ACS Pharmacol.Transl.Sci. 2023 PMID: 37588763