DSRM-3716

Name: DSRM-3716
Brand: Tocris Bioscience
SKU: 7414

Tocris Bioscience, part of Bio-Techne | Catalog # 7414

Citations (5)

COA / SDS

Potent and reversible SARM1 NAD hydrolase inhibitor

Key Product Details

Description:	Potent and reversible SARM1 NAD hydrolase inhibitor
Chemical Name:	5-Iodoisoquinoline
Purity:	≥98% (HPLC)
Molecular Weight:	255.06

View Full Technical Details for DSRM-3716

Technical Data
Citations

Biological Activity for DSRM-3716

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC₅₀ = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.

Technical Data for DSRM-3716

M. Wt	255.06
Formula	C₉H₆IN
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	58142-99-7
PubChem ID	11391181
InChi Key	CUILFTFMBBGSFT-UHFFFAOYSA-N
Smiles	IC1=CC=CC=2C=NC=CC12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DSRM-3716

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	25.51	100
	DMSO	25.51	100

Preparing Stock Solutions for DSRM-3716

The following data is based on the product molecular weight 255.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.92 mL	19.60 mL	39.21 mL
5 mM	0.78 mL	3.92 mL	7.84 mL
10 mM	0.39 mL	1.96 mL	3.92 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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References for DSRM-3716

References are publications that support the biological activity of the product.

O Hughes Small molecules SARM1 inhibitors recapitulate the SARM1-/- phenotype and allow recovery of a metastable pool of axons fated to degenerate. Cell Rep. 2021 PMID: 33406435