DPO-1 is a blocker of I_Kur ultrarapid delayed rectifier potassium current and K_V1.5 channels (IC₅₀ = 0.31 μM for rK_V1.5). Displays selectivity for inhibition of I_Kur over I_to (8-fold), I_K1, I_Kr and I_Ks (20-fold) in native myocytes and selectivity for rat recombinant K_V1.5 over K_V3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.

Product Specifications

Molecular Weight

340.44

Formula

C₂₂H₂₉OP

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide

CAS Number

43077-30-1

PubChem ID

21678144

InChI Key

BPCNGVCAHAIZEE-COPCDDAFSA-N

SMILES

C[C@@H]1CC[C@@H]([C@@H](C)C)[C@@H]([P@@](C2=CC=CC=C2)(C3=CC=CC=C3)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	Ethanol	34.04	100

Preparing Stock Solutions for DPO-1

The following data is based on the product molecular weight 340.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.37 mL
5 mM	0.59 mL	2.94 mL	5.87 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Background References

References are publications that support the biological activity of the product.

Regan In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide I_Kur blocker, (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. J.Pharmacol.Exp.Ther. 2006 PMID: 16243963
Lagrutta Novel, potent inhibitors of human Kv1.5 K⁺ channels and ultrarapid activating delayed rectifier potassium current. J.Pharmacol.Exp.Ther. 2006 PMID: 16522807
Stump In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide I_Kur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J.Pharmacol.Exp.Ther. 2005 PMID: 16157659

DPO-1

Tocris Bioscience, part of Bio-Techne | Catalog # 2533

Key Product Details

Description

Alternative Names

View all Voltage-gated Potassium Channel Blockers »

Product Description