DPN
Tocris Bioscience, part of Bio-Techne | Catalog # 1494
Highly potent ERβ agonist
Key Product Details
Description
Highly potent ERβ agonist
Alternative Names
Diarylpropionitrile
Product Description
DPN is a highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα (EC50 values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro. Shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus.Product Specifications
Molecular Weight
239.27
Formula
C15H13NO2
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
2,3-bis(4-Hydroxyphenyl)-propionitrile
CAS Number
1428-67-7
PubChem ID
102614
InChI Key
GHZHWDWADLAOIQ-UHFFFAOYSA-N
SMILES
OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.93 | 100 | |
| 1eq. NaOH | 7.18 | 30 | |
| Ethanol | 23.93 | 100 |
Preparing Stock Solutions
for DPN
The following data is based on the product molecular weight 239.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.18 mL | 20.90 mL | 41.79 mL |
| 5 mM | 0.84 mL | 4.18 mL | 8.36 mL |
| 10 mM | 0.42 mL | 2.09 mL | 4.18 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Waters Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus. Brain Res. 2009 PMID: 19596275
- Meyers Estrogen receptor-β potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J.Med.Chem. 2001 PMID: 11708925
- Montgomery Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility. Br.J.Pharmacol. 2003 PMID: 12890703
- Harrington Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 2003 PMID: 12943986
Product Specific Notices for DPN
For research use only
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