DMCM hydrochloride

Name: DMCM hydrochloride
Brand: Tocris Bioscience
SKU: 3083

Tocris Bioscience, part of Bio-Techne | Catalog # 3083

Citations (6)

COA / SDS

Benzodiazepine inverse agonist

Key Product Details

Description:	Benzodiazepine inverse agonist
Chemical Name:	4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	350.8

View Full Technical Details for DMCM hydrochloride

Technical Data
Citations

Biological Activity for DMCM hydrochloride

DMCM hydrochloride is a benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.

Compound Libraries for DMCM hydrochloride

DMCM hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DMCM hydrochloride

M. Wt	350.8
Formula	C₁₇H₁₈N₂O₄.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1215833-62-7
PubChem ID	45261899
InChi Key	FHCRBVQGMZUJKY-UHFFFAOYSA-N
Smiles	CCC1=C(C(OC)=O)N=CC3=C1C2=CC(OC)=C(OC)C=C2N3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMCM hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.43	100
	DMSO	7.02	20

Preparing Stock Solutions for DMCM hydrochloride

The following data is based on the product molecular weight 350.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.25 mL	28.51 mL
5 mM	0.57 mL	2.85 mL	5.70 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Reconstitution Calculator

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References for DMCM hydrochloride

References are publications that support the biological activity of the product.

Conto Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 2005 PMID: 16297441
Sieve Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 2001 PMID: 11205417
Petersen DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 1983 PMID: 6317396