Dimethylenastron

Name: Dimethylenastron
Brand: Tocris Bioscience
SKU: 5261

Tocris Bioscience, part of Bio-Techne | Catalog # 5261

Citations (3)

COA / SDS

Inhibitor of mitotic motor kinesin Eg5

Discontinued Product

5261 has been discontinued. View all Kinesin Inhibitors products.

Key Product Details

Description:	Inhibitor of mitotic motor kinesin Eg5
Chemical Name:	2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
Purity:	≥99% (HPLC)
Molecular Weight:	302.39

View Full Technical Details for Dimethylenastron

Technical Data
Citations

Biological Activity for Dimethylenastron

Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC₅₀ = 200 nM). Arrests mitosis, triggers apoptosis and up-regulates Hsp-70 expression in multiple human myeloma cell lines. Also inhibits the growth of several types of cancer cell lines (EC₅₀ values are 330, 603, 743 and 881 nM in HCT116, Htert-HME1, BxPC3, K562 and NCI-H1299 cancer cells, respectively). Suppresses the migration and invasion of PANC1 cells in vitro. Cytoprotective.

Technical Data for Dimethylenastron

M. Wt	302.39
Formula	C₁₆H₁₈N₂O₂S
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	863774-58-7
PubChem ID	11609157
InChi Key	RUOOPLOUUAYNPY-UHFFFAOYSA-N
Smiles	O=C1CC(C)(C)CC2=C1C(C3=CC=CC(O)=C3)NC(N2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Dimethylenastron

References are publications that support the biological activity of the product.

Liu Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells. J.Biol.Chem. 2006 PMID: 16627469
Sun Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. Acta.Pharmacol Sin. 2011 PMID: 21986572
Kaan Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. J.Med.Chem. 2010 PMID: 20597485

Dimethylenastron

Tocris Bioscience, part of Bio-Techne | Catalog # 5261

Key Product Details

Biological Activity for Dimethylenastron

Technical Data for Dimethylenastron

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Dimethylenastron

Product Documents for Dimethylenastron

COA

Certificate of Analysis

SDS

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