DIDS

Tocris Bioscience, part of Bio-Techne | Catalog # 4523

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor
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Key Product Details

Description

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

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Product Description

DIDS is a ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).

Product Specifications

Molecular Weight

498.48

Formula

C16H8N2Na2O6S4

Storage

Store at +4°C

Purity

≥95% (HPLC)

Chemical Name

4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt

CAS Number

67483-13-0

PubChem ID

5702690

InChI Key

GEPAYBXVXXBSKP-SEPHDYHBSA-L

SMILES

[Na+].[Na+].[O-]S(=O)(=O)C1=C(\C=C\C2=C(C=C(C=C2)N=C=S)S([O-])(=O)=O)C=CC(=C1)N=C=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Potassium bicarbonate (0.1M) 2.49 5

Preparing Stock Solutions for DIDS

The following data is based on the product molecular weight 498.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 40.12 mL 200.61 mL 401.22 mL
0.25 mM 8.02 mL 40.12 mL 80.24 mL
0.5 mM 4.01 mL 20.06 mL 40.12 mL
2.5 mM 0.80 mL 4.01 mL 8.02 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for DIDS

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DIDS

For research use only

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