DG 041
Tocris Bioscience, part of Bio-Techne | Catalog # 6240
Potent and selective EP3 antagonist; antiplatelet and antithrombotic
Key Product Details
Description
Potent and selective EP3 antagonist; antiplatelet and antithrombotic
Product Description
DG 041 is a potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.Product Specifications
Molecular Weight
592.32
Formula
C23H15Cl4FN2O3S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide
CAS Number
861238-35-9
PubChem ID
11296282
InChI Key
BFBTVZNKWXWKNZ-HWKANZROSA-N
SMILES
CC1=CN(C2=C(C=C(C=C12)F)/C=C/C(NS(=O)(C3=CC(Cl)=C(S3)Cl)=O)=O)CC4=C(C=C(C=C4)Cl)Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.23 | 100 |
Preparing Stock Solutions
for DG 041
The following data is based on the product molecular weight 592.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.69 mL | 8.44 mL | 16.88 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.69 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Singh Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem.Biol. 2009 PMID: 19193156
- Markovič Structural features of subtype-selective EP receptor modulators. Drug Discov.Today. 2017 PMID: 27506873
Product Specific Notices for DG 041
For research use only
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