Dexfenfluramine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2695
5-HT reuptake inhibitor; also stimulates 5-HT release
Key Product Details
Description
5-HT reuptake inhibitor; also stimulates 5-HT release
Alternative Names
(+)-Fenfluramine
Product Description
Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.Product Specifications
Molecular Weight
267.72
Formula
C12H16F3N.HCl
Storage
Desiccate at RT
Purity
≥95% (HPLC)
Chemical Name
(S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
CAS Number
3239-45-0
PubChem ID
66264
InChI Key
ZXKXJHAOUFHNAS-FVGYRXGTSA-N
SMILES
C[C@H](NCC)CC1=CC=CC(C(F)(F)F)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.77 | 100 | |
| DMSO | 26.77 | 100 |
Preparing Stock Solutions
for Dexfenfluramine hydrochloride
The following data is based on the product molecular weight 267.72
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.74 mL | 18.68 mL | 37.35 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.47 mL |
| 10 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Higgins Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. Br.J.Pharmacol. 2001 PMID: 11399662
- Bush Chronic treatment with either dexfenfluramine or sibutr. in diet-switched diet-induced obese mice. Endocrine 2006 PMID: 16785615
- Caccia Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluox. Pharmacol.Biochem.Behav. 1997 PMID: 9259015
Product Specific Notices for Dexfenfluramine hydrochloride
For research use only
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