des-His¹-[Glu⁹]-Glucagon (1-29) amide

Name: des-His 1 -[Glu 9 ]-Glucagon (1-29) amide
Brand: Tocris Bioscience
SKU: 2216

Tocris Bioscience, part of Bio-Techne | Catalog # 2216

Citations (4)

COA / SDS

Glucagon receptor antagonist

Key Product Details

Description:	Glucagon receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	3358.68

View Full Technical Details for des-His¹-[Glu⁹]-Glucagon (1-29) amide

Technical Data
Citations

Biological Activity

des-His¹-[Glu⁹]-Glucagon (1-29) amide is a glucagon receptor antagonist (pA₂ = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.

Technical Data

M. Wt	3358.68
Formula	C₁₄₈H₂₂₁N₄₁O₄₇S
Single Letter Sequence	SQGTFTSEYSKYLDSRRAQDFVQWLMNT (Modifications: Thr-28 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	110084-95-2
PubChem ID	16133829
InChi Key	RVXSASLSNHDASC-OSWDIKPLSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 1mg/ml in water

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References

References are publications that support the biological activity of the product.

Huypens Glucagon receptors on human islet cells contribute to glucose competence of Ins release. Diabetologia 2000 PMID: 10990079
Unson Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA
Unson Biological activities of des-His¹[Glu⁹]glucagon amide, a glucagon antagonist. Peptides 1989 PMID: 2560175

des-His¹-[Glu⁹]-Glucagon (1-29) amide

Tocris Bioscience, part of Bio-Techne | Catalog # 2216

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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des-His1-[Glu9]-Glucagon (1-29) amide

Tocris Bioscience, part of Bio-Techne | Catalog # 2216

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

des-His¹-[Glu⁹]-Glucagon (1-29) amide