Deazaflavin, Alkyne

Name: Deazaflavin, Alkyne
Brand: Tocris Bioscience
SKU: 8986

Tocris Bioscience, part of Bio-Techne | Catalog # 8986

COA / SDS

Photosensitizer for proximity labeling experiments, Alkyne reactive group

Key Product Details

Description:	Photosensitizer for proximity labeling experiments, Alkyne reactive group
Chemical Name:	3-(Hex-5-yn-1-yl)-10-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
Purity:	≥95% (HPLC)
Molecular Weight:	307.35

View Full Technical Details for Deazaflavin, Alkyne

Technical Data
Citations

Biological Activity for Deazaflavin, Alkyne

Deazaflavin, Alkyne is a deazaflavin-based organic photocatalyst bearing a terminal alkyne functional group for use in bioorthogonal conjugation strategies such as copper-catalyzed azide-alkyne cycloaddition (CuAAC). Upon blue light illumination (~450 nm), the deazaflavin photocatalyst undergoes excitation and enables Dexter-type triplet energy transfer to nearby photoactivatable functional groups such as diazirines or aryl azides, leading to covalent labeling of proximal proteins or biomolecules. When tethered to a targeting ligand, peptide, or macromolecule via the alkyne handle, the reagent allows proximity-dependent photolabeling in live cells or complex biological environments.

Technical Data for Deazaflavin, Alkyne

M. Wt	307.35
Formula	C₁₈H₁₇N₃O₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	JEQHRFJFVRKSCU-UHFFFAOYSA-N
Smiles	O=C1N(CCCCC#C)C(C2=CC3=CC=CC=C3N(C)C2=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Deazaflavin, Alkyne

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.07	10

Preparing Stock Solutions for Deazaflavin, Alkyne

The following data is based on the product molecular weight 307.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.54 mL	162.68 mL	325.36 mL
0.5 mM	6.51 mL	32.54 mL	65.07 mL
1 mM	3.25 mL	16.27 mL	32.54 mL
5 mM	0.65 mL	3.25 mL	6.51 mL

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References for Deazaflavin, Alkyne

References are publications that support the biological activity of the product.

Crocker Energy-transfer photoproximity labelling in live cells using an organic cofactor. Nat.Chem. 2025 PMID: 40962911