DCLK1-IN-1
Tocris Bioscience, part of Bio-Techne | Catalog # 7285
Potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor; orally bioavailable
Key Product Details
Description
Potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor; orally bioavailable
Product Description
DCLK1-IN-1 is a potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor (IC50 values are DCLK1 =9.5 and 57.2 nM and DCLK2 = 31 and 103 nM in binding and kinase assay, respectively). Exhibits no significant activity against ERK5, ACK, BRD4 and LRRK2. Exhibits DCLK inhibition in pancreatic ductal adenocarcinoma (PDAC) organoid models. Orally bioavailable.Licensing Information
Sold under license from Dana-Farber Cancer InstituteExternal Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DCLK1-IN-1 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
527.55
Formula
C26H28F3N7O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5-(2,2,2-trifluoroethyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
CAS Number
2222635-15-4
PubChem ID
134457640
InChI Key
OQFCHSFVWSLDAO-UHFFFAOYSA-N
SMILES
COC1=C(C=CC(N2CCN(CC2)C)=C1)NC3=NC=C4N(C(C5=CC=CC=C5N(C4=N3)C)=O)CC(F)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.76 | 100 | |
| Ethanol | 52.76 | 100 |
Preparing Stock Solutions
for DCLK1-IN-1
The following data is based on the product molecular weight 527.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.90 mL | 9.48 mL | 18.96 mL |
| 5 mM | 0.38 mL | 1.90 mL | 3.79 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.90 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ferguson Discovery of a selective inhibitor of doublecortin like kinase 1. Nat.Chem.Biol. 2020 PMID: 32251410
Product Specific Notices for DCLK1-IN-1
For research use only
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