DBIA
Tocris Bioscience, part of Bio-Techne | Catalog # 8142
Chemoproteomic reagent, binds with reactive cysteines and labels with desthiobiotin
Key Product Details
Description
Chemoproteomic reagent, binds with reactive cysteines and labels with desthiobiotin
Product Description
DBIA (desthiobiotin iodoacetamide) is a chemoproteomic reagent. DBIA is a cysteine reactive probe used to label and purify proteins by attaching desthiobiotin to cysteine residues in the protein of interest. DBIA can be used for targeted protein labeling and purification studies.Product Specifications
Molecular Weight
424.28
Formula
C14H25IN4O3
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(4R,5S)-N-[2-[(2-Iodoacetyl)amino]ethyl]-5-methyl-2-oxo-4-imidazolidinehexanamide
CAS Number
2924824-04-2
PubChem ID
166642567
InChI Key
ASKKBTGJVCEXOA-WDEREUQCSA-N
SMILES
ICC(NCCNC(CCCCC[C@@H]1[C@@H](NC(N1)=O)C)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.43 | 100 |
Preparing Stock Solutions
for DBIA
The following data is based on the product molecular weight 424.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.36 mL | 11.78 mL | 23.57 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kuljanin Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat.Biotechnol. 2021 PMID: 33398154
Product Specific Notices for DBIA
For research use only
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