Darapladib
Tocris Bioscience, part of Bio-Techne | Catalog # 6755
Potent lp-PLA2 inhibitor
Product Description
Darapladib is a potent lipoprotein-associated phospholipase A2 (lp-PLA2) inhibitor (IC50 = 5 nM in whole human plasma).Product Specifications
Molecular Weight
666.77
Formula
C36H38F4N4O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide
CAS Number
356057-34-6
PubChem ID
9939609
InChI Key
WDPFJWLDPVQCAJ-UHFFFAOYSA-N
SMILES
CCN(CCN(C(CN1C2=C(C(N=C1SCC3=CC=C(C=C3)F)=O)CCC2)=O)CC4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 66.68 | 100 | |
| Ethanol | 66.68 | 100 |
Preparing Stock Solutions
for Darapladib
The following data is based on the product molecular weight 666.77
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.50 mL | 7.50 mL | 15.00 mL |
| 5 mM | 0.30 mL | 1.50 mL | 3.00 mL |
| 10 mM | 0.15 mL | 0.75 mL | 1.50 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Blackie The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg.Med.Chem.Lett. 2003 PMID: 12643913
Product Specific Notices for Darapladib
For research use only
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