DADLE

Name: DADLE
Brand: Tocris Bioscience
SKU: 3790

Tocris Bioscience, part of Bio-Techne | Catalog # 3790

Citations (11)

COA / SDS

Prototypical δ agonist

Discontinued Product

3790 has been discontinued. View all delta Opioid Receptor Agonists products.

Key Product Details

Description:	Prototypical δ agonist
Alternative Names:	[D-Ala²,D-Leu⁵]-Enkephalin
Purity:	≥95% (HPLC)
Molecular Weight:	569.66

View Full Technical Details for DADLE

Technical Data
Citations

Biological Activity for DADLE

DADLE is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.

Technical Data for DADLE

M. Wt	569.66
Formula	C₂₉H₃₉N₅O₇
Single Letter Sequence	YAGFL (Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	63631-40-3
PubChem ID	6917707
InChi Key	ZHUJMSMQIPIPTF-IBURTVSXSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for DADLE

References are publications that support the biological activity of the product.

Ke Delta opioid agonist [D-Ala², D-Leu⁵] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res. 2009 PMID: 19619518
Suh and Tseng Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice. Naunyn-Schmied.Arch.Pharmacol.
Mulder Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain. Br.J.Pharmacol. 1991 PMID: 1673074

DADLE

Tocris Bioscience, part of Bio-Techne | Catalog # 3790

Key Product Details

Biological Activity for DADLE

Technical Data for DADLE

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DADLE

Product Documents for DADLE

COA

Certificate of Analysis

SDS

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