D609
Tocris Bioscience, part of Bio-Techne | Catalog # 1437
Selective PC-PLC inhibitor
Product Description
D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.Product Specifications
Molecular Weight
266.46
Formula
C11H15OS2K
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
CAS Number
83373-60-8
PubChem ID
4234241
InChI Key
IGULCCCBGBDZKQ-UHFFFAOYSA-M
SMILES
S=C(S[K])OC1CC2C3CCCC3C1C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.65 | 100 |
Preparing Stock Solutions
for D609
The following data is based on the product molecular weight 266.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.76 mL | 37.53 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.51 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Adibhatla Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem.Res. 2012 PMID: 22101393
- Tschiakowsky Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 1994 PMID: 7532078
- Zhou D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 2001 PMID: 11408530
- Amtmann The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 1996 PMID: 9034754
Product Specific Notices for D609
For research use only
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