D-Amphetamine sulfate

Name: D-Amphetamine sulfate
Brand: Tocris Bioscience
SKU: 2813

Tocris Bioscience, part of Bio-Techne | Catalog # 2813

Citations (30)

COA / SDS

Induces dopamine, 5-HT and noradrenalin release; also α7 nAChR antagonist

Key Product Details

Description:	Induces dopamine, 5-HT and noradrenalin release; also α7 nAChR antagonist
Alternative Names:	Dextroamphetamine sulfate
Chemical Name:	(+)-α-Methylphenethylamine hemisulfate salt
Purity:	≥98% (HPLC)
Molecular Weight:	184.25

View Full Technical Details for D-Amphetamine sulfate

Technical Data
Citations

Biological Activity for D-Amphetamine sulfate

D-Amphetamine sulfate is a cNS stimulant. Targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin. Also α7 nAChR antagonist.

Technical Data for D-Amphetamine sulfate

M. Wt	184.25
Formula	C₉H₁₃N.1/₂H₂SO₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	51-63-8
PubChem ID	5825
InChi Key	PYHRZPFZZDCOPH-QXGOIDDHSA-N
Smiles	N[C@@H](C)CC1=CC=CC=C1.N[C@@H](C)CC2=CC=CC=C2.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D-Amphetamine sulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	18.43	100

Preparing Stock Solutions for D-Amphetamine sulfate

The following data is based on the product molecular weight 184.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.43 mL	27.14 mL	54.27 mL
5 mM	1.09 mL	5.43 mL	10.85 mL
10 mM	0.54 mL	2.71 mL	5.43 mL
50 mM	0.11 mL	0.54 mL	1.09 mL

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Reconstitution Calculator

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References for D-Amphetamine sulfate

References are publications that support the biological activity of the product.

Garton Amphetamine enantiomers inhibit homomeric a7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans. Neuropharmacology 2018 PMID: 30359640
Cartmell The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-Amphetamine motor behaviors in rats. J.Pharmacol.Exp.Ther. 1999 PMID: 10490900
Rothman and Baumann Balance between DA and serotonin release modulates behavioral effects of Amphetamine-type drugs. Ann.N.Y.Acad.Sci. 2006 PMID: 17105921
Barr Effects of withdrawal from an escalating dose schedule of d-Amphetamine on sexual behavior in the male rat. Pharmacol.Biochem.Behav. 1999 PMID: 10548277